In order of priority but not order of release.

DDO - Issue3.  Ok, its not an "upcoming game" as much as it is an upcoming patch, but I'm really looking forward to this.  An illithid who sucks out feats from your brain in return for gold is a nice Eberron way of handling a very MMO issue, character respecs.  Combat changes making ranged characters more viable (being able to move while reloading is going to be "fantastic").  consensual pvp (I generally don't like pvp, but it can be fun here and there), and of course more dungeons. :)   

Eve Online - Kali.  Space exploration, salvage operations?  I think this is going to be great.  With the remnants of the old agent system completely removed, this should be good.

Marvel Ultimate Alliance:  I'm a big fan of the 2 x-men games they released using this engine, and hoping that this game will be even better.  Whats nice is they are doing some heavy advertising of it, here is my obligatory banner for my vip.

Might and Magic - Dark Messiah.  This game should be fantastic, I downloaded the 1.5 gig demo and it was really done very well.  I don't usually have time for single-player adventure games, but I'll give this game a good try.

Anything else upcoming? I can't think of it.  Anyone play in Eve or DDO (or going to give them a try)?  Check out the dndorks MMO page for information about playing with us now and again.