As with many things, genetic manipulation is not wrong in itself, but rhater in how it is applied. I work in a lab, and I am all for genetic research that has the potential to cure, or at least give hope, to people with chronic, debilitating conditions. That goat btw doesn't produce spiderwebs in place of milk, but it's milk contains a protein that enters the making of spiderwebs.
Where things get complicated is when it comes to its application to humans. Right now some are concerned that insurance companies will require DNA testing, this in order to better assess their risks in insuring an individual. That would be a clear violation of basic human rights.
Now lets take the case of a pregnant mother. She learns that her child will be born with a defect, and that this can be corrected by genetic technology. I don't think it would be wrong to give this child a chance to a normal life, but what are other conditions that would qualify as 'defects'?
I brings to mind the movie Welcome To Gattaga. In it you had the ones genetically modified, termed Valids, and those not improved where termed Invalids. If you haven't seen the movie, I strongly recommend you rent it, as it explores this issue in a realistic manner. The bottom line is, to my mind, that something that is able to improve human life shouldn't be reserved to a few elites, but allow for all to profit from it. Unfortunately, that is unrealistic and utopic.
Beauty In Diversity